By Stefan H. E. Kaufmann, Bruce D. Walker
Delivering the most recent info on preventive, diagnostic and healing facets of tuberculosis and AIDS, this can be the single publication to put a massive emphasis at the expanding coexistence of those life-threatening illnesses in individuals.
Edited by way of notable scientists within the box, this prepared reference is split into 3 major sections masking immunology and vaccination concepts, medicines, and scientific issues.
well timed analyzing for microbiologists, virologists, bacteriologists, immunologists, and pathophysiologists, in addition to for the pharmaceutical and biotechnological industries.
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Extra resources for AIDS and Tuberculosis: A Deadly Liaison
This observation may be at least partially explained by immuneinduced mutations, which would be expected to have a greater impact on viral ﬁtness when arising in key structural or functional proteins, as opposed to the envelope protein, which is able to accommodate extensive sequence variation. Durable control of AIDS virus infection has also been achieved with live attenuated vaccines, which by far have had the most impressive effect of any vaccine tested. So far, a live attenuated SIV represents the most successful nonhuman primate vaccine approach, and has consistently protected rhesus macaques against challenge with a homologous, pathogenic SIV .
J. , 73, 8356–8363. D. P. (2005) Kinetics of expansion of SIV Gag-speciﬁc CD8 þ T lymphocytes following challenge of vaccinated macaques. Virology, 333, 226–238. L. P. (2004) Phase I/II study of a candidate vaccine designed against the B and E subtypes of HIV-1. J. Acquir. Immune Deﬁc. , 37, 1160–1165. K. W. (1990) Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature, 345, 622–625. A. S. (1995) Resistance of chimpanzees immunized with recombinant gp120SF2 to challenge by HIV-1SF2.
1993) Immunization with recombinant BCG-SIV elicits SIV-speciﬁc cytotoxic T lymphocytes in rhesus monkeys. J. , 150, 3101–3107. , Yamazaki, A. and Yamazaki, S. (1995) Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guerin vector candidate vaccine for human immunodeﬁciency virus type 1 in small animals. Proc. Natl Acad. Sci. USA, 92, 10693–10697. R. L. (2006) Generation of CD8 þ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeﬁciency virus type 1 Env.
AIDS and Tuberculosis: A Deadly Liaison by Stefan H. E. Kaufmann, Bruce D. Walker