New PDF release: Bone Marrow Transplant - A Medical Dictionary, Bibliography,

By Icon Health Publications

ISBN-10: 0597843589

ISBN-13: 9780597843587

ISBN-10: 1417512768

ISBN-13: 9781417512768

This can be a 3-in-1 reference ebook. It provides a whole clinical dictionary masking hundreds of thousands of phrases and expressions in terms of bone marrow transplant. It additionally supplies vast lists of bibliographic citations. eventually, it presents info to clients on find out how to replace their wisdom utilizing numerous web assets. The booklet is designed for physicians, scientific scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with learn devoted to bone marrow transplant. in the event that your time is effective, this publication is for you. First, you won't waste time looking out the web whereas lacking loads of proper info. moment, the ebook additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing thousands of web content.

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Additional info for Bone Marrow Transplant - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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First, HDC induces an intense oxidative stress resulting in both lung tissue injury and increases in monocyte chemo attractant protein-1 (MCP-1). Second, in response primarily to MCP-1 (and MIP-1a), pulmonary inflammatory cells are recruited into the lung, which possess antigen presenting cells (APC) features and may further stimulate a T cell lymphocyte response. Finally, fibroblast growth factors, like FGF-2, initiate a lung repair and fibrotic response. We plan to test these hypotheses by utilizing mouse strains that 1) overexpress and under express (knockout) antioxidant enzymes, 2) overexpress MCP-1, and 3) are deficient in CCR2.

Professor; Vanderbilt University 3319 West End Ave. Nashville, Tn 372036917 Timing: Fiscal Year 2002; Project Start 01-APR-1992; Project End 31-MAR-2007 Summary: Description (provided by applicant) Transforming growth factor-beta 1 (TGFbeta) has been implicated as a key molecule in fibrosis, and its expression is increased in numerous fibrotic conditions. The relationship of TGFbeta to other profibrotic mechanisms, such as angiotensin and plasminogen activator inhibitor-1 (PAI-1), and the differential role of infiltrating versus parenchymal cells are complex.

The following hypothesis will be tested in the proposed research project: The therapeutic effect of DLI is mediated by a distinguishable population of donor-derived, MHC- restricted T cells responding to both allogeneic and leukemia-specific stimuli. Three Specific Aims are proposed: 1) To characterize at cellular and molecular levels the T cell response to a leukemia-specific peptide (bcr-abl) in the absence (autologous) and presence (allogeneic) of various degrees of major and minor histoincompatibility; (2) To characterize at cellular and molecular levels the T cell response to intact CML cells, compare this response to that generated by the bcr-abl peptide, and evaluate how alloreactivity alters these responses; and (3) To assess the repertoire of T cells in the peripheral blood of patients given DLI for CML and compare the in vivo T cell repertoire to that identified in vitro in Specific Aims 1 and 2 to distinguish alloreactive and leukemia-reactive T-cells.

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Bone Marrow Transplant - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications


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