Cancer. A Comprehensive Treatise: Volume 1. Etiology: by Peter C. Nowell (auth.), Frederick F. Becker (eds.) PDF

By Peter C. Nowell (auth.), Frederick F. Becker (eds.)

ISBN-10: 1461344492

ISBN-13: 9781461344490

ISBN-10: 1461344514

ISBN-13: 9781461344513

This sequence of books makes an attempt to offer, in a complete demeanour, the sector of oncology divided into 3 significant parts; etiology, biology, and remedy. those books may still function landmarks within the swiftly increasing experimental and medical "universe" of this box. to a couple, they are going to be introductory; to others, a precis; for all, severe reviews at the futuI'e of analysis. In l'ecognition of the problems inherent in trying to pause and mirror whereas experimental information emerge with ever-increasing rapidity, the shows take the shape of overviews instead of experiences. the place attainable, an ancient viewpoint on observations and experimentation which resulted in our current knowing is gifted, the state-of-the-art in procedure and process is reviewed, and the gaps in wisdom and in strategy are indicated. the purpose all through is integration-using the findings from one strategy for comparability with others. The large growth of curiosity in oncology as a medical-biological self-discipline encouraged the e-book of those volumes. This enlargement, good warranted when it comes to the impression of oncology on human morbidity, has been characterised via a minimum of 3 phenomena. First, there was a tremendous bring up in cash and manpower dedicated to the research and remedy of malignancy. That the learn has develop into a growing number of "directed" or program-oriented signs the curiosity of these past the medical neighborhood within the administration of the eHort. moment, expanding numbers of scholars are getting into the sector of oncology as their significant education program.

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Extra info for Cancer. A Comprehensive Treatise: Volume 1. Etiology: Chemical and Physical Carcinogenesis

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LLOS, G. , CARBONE, P. , Ai'

27:806. TODARO, G. , AND SWIFT, M. , 1966, Human diploid fibroblasts transformed with SV40 or hybrid Adeno-7x SV40, Science 153:1252. TRUJILLO, J. , 1963, Chromosomal alteration of erythropoietic cells in chronic myeloid leukemia, Acta Haematol. 29:311. , 1890 Uber asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung, Virchows Arch. Pathol. Anat. Physiol. 119:298. , UPTON, A. , JDIKINS, V. , Ai'<]) BORGES, W. , 1964, Mouse post-irradiation leukemia: Consistent occurrence of an extra and a marker chromosome, Science 143:810.

NOWELL I FIGURE 3. Metaphase from a squamous cell carcinoma of the skin. There are 87 chromosomes including two large abnormal "marker" chromosomes (arrows) which helped characterize the predominant cell clone in this tumor. This degree of hyperploidy is not uncommon in solid malignancies. , 1970). 2. Benign and Precancerous Lesions In agreement with the meningioma data, chromosome studies on other human benign and "premalignant" lesions have also revealed a rough correlation between degree of histological abnormality and the extent of cytogenetic change.

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Cancer. A Comprehensive Treatise: Volume 1. Etiology: Chemical and Physical Carcinogenesis by Peter C. Nowell (auth.), Frederick F. Becker (eds.)


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