P. Sassone-Corsi, S. J. Busch, F. Schlotter, J. Auwerx, B.'s Chemical Carcinogenesis 2: Modulating Factors PDF

By P. Sassone-Corsi, S. J. Busch, F. Schlotter, J. Auwerx, B. Mellström, N. S. Foulkes (auth.), Amedeo Columbano, Francesco Feo, Rosa Pascale, Paolo Pani (eds.)

ISBN-10: 1461366429

ISBN-13: 9781461366423

ISBN-10: 1461536944

ISBN-13: 9781461536949

"chemical carcinogenesis" is the overall identify of the sequence of overseas conferences that are held, biannually, in sardinia (Italy) due to the fact 1981. regardless of the generality of the identify, the most attempt of the clinical Committee has been to pursue a coherent line round essentially the most distinguishing good points of carcinogenesis: the "multifasic" improvement of the method. provided that many chemicals are recognized to reason "experimental cancer", many questions nonetheless stay unresolved or are given too simplistic solutions. the first actual query about the interplay among the chemical carcinogen and the molecular goal within the telephone is a controversial one regardless of the overpowering literature during this box. it truly is sure that chemical cancer agents are poisonous to cells and reason DNA harm: but it remains to be an open query as to the right way to relate those alterations to different levels of carcinogenesis together with initiation. we haven't to fail to remember that 0.33 to 2/3 of the typical existence time of a given species elapses among the experimental management of the carcinogen and the looks of "cancer". The experimental manipulation of carcinogenesis by utilizing "adequate organic types" has now not simplified the issues approximately melanoma, however it has led us to stand the complexity of another way hassle-free organic homes, cellphone proliferation and differentiation. the certainty of this organic complexity isn't just theoretical, however it can give us these sufficient conceptual instruments to strategy "cancer" additionally from a scientific element of view.

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Extra resources for Chemical Carcinogenesis 2: Modulating Factors

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Columbano, s. Rajalakshmi, and D. s. R. Sarma, Requirement of cell proliferation for the initiation of liver carcinogenesis as assayed by three different procedures, Cancer Res. 41:2079 (1981). A. columbano, G. M. Ledda-columbano, P. coni, G. Faa, c. Liguori, G. santacruz, and P. Pani, Occurrence of cell death (apoptosis) during the involution of liver hyperplasia, Lab. Invest. 52:670 (1985). A. Columbano, G. M. Ledda-columbano, G. Lee, S. Rajalakshmi, and D. s. R. Sarma, Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered islands by liver carcinogenesis, Cancer Res.

Garcea, L. Daino, and R. Pascale, Mechanism of the inhibition of liver hepatocarcinogenesis promotion by s-adenosyl-L-methionine, in: "Experimental Hepatocarcinogenesis," M. B. Roberfroid, and V. , Plenum Publ. , New York, (1988) . K. Enomoto, and E. Farber, Kinetics of phenotypic maturation of remodelling of hyperplastic nodules during liver carcinogenesis, Cancer Res. 42:2330 (1982). M. A. Moore, J. Hacker, and P. Bannasch, Phenotypic instability in focal and nodular lesions induced by a short term system in the rat liver, carcinogenesis 4:595 (1983).

A striking increase in the expression of this protooncogene was also found during cc14 induced liver regeneration (Figure 2). Interestingly the expression of c-myc during direct hyperplasia induced by different mitogens showed striking differences depending on the Table 1. Effect of various proliferative Stimuli on Labelled Thymidine Incorporation Into Hepatic DNA Treatment Time of sacrifice (h) Control 24 16 ± 7 PH 24 75 ± 18 EDB 24 42 ± 16 CPA 24 68 ± 13 pb 36 61 + 8 Liver cell proliferation was induced by PH, EDB (100 mg/kg), CPA (60 mg/kg) or Lead Nitrate (pb, 100 micromoles/kg).

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Chemical Carcinogenesis 2: Modulating Factors by P. Sassone-Corsi, S. J. Busch, F. Schlotter, J. Auwerx, B. Mellström, N. S. Foulkes (auth.), Amedeo Columbano, Francesco Feo, Rosa Pascale, Paolo Pani (eds.)


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