Chemical Probes in Biology: Science at the Interface of - download pdf or read online

By Jason P. Eiserich (auth.), Manfred P. Schneider (eds.)

ISBN-10: 1402017707

ISBN-13: 9781402017704

ISBN-10: 9400709587

ISBN-13: 9789400709584

This NATO complicated research Institute (co-sponsored via FEBS and INTAS) below the name "Chemical Probes in Biology" used to be designed to summarize and disseminate contemporary professional wisdom relating to a deeper realizing ofbiological phenomena on a molecular point. Such medical actions -frequently termed Bio-organic Chemistry or Chemical Biology ­ are constituting a hugely interdisciplinary department of chemistry past the conventional ways that chemists and biologists were operating long ago. hence, in this party we have been bringing jointly senior specialists from the disciplines of Chemistry and Biology with the intention to amalgamate their different but primarily universal pursuits during this quarter. final target was once - subsequent to an alternate of knowledge among the 2 medical cultures - the verbal exchange ofexciting percentages in interdisciplinary examine to the younger scientists current. The assembly used to be held within the Anargyros and Korgialenios college at the Island ofSpeteses, Greece from 18-30 August 2002. The ASI used to be attended by means of a complete of ninety one students from 23 diverse international locations. a gaggle of 27 audio system provided a chain of 34 hugely stimulating, informative and academic lectures overlaying a extensive diversity of themes proper to the final subject matter ofthis assembly: technology on the InteifaceofChemistry, Biology and drugs. The lectures have been complemented through a complete of 89 posters provided through the younger students and a sequence of brief lectures derived thereof This was once in actual fact one ofthe highlites of the assembly making a full of life surroundings of interplay and highbrow creativity - average phenomena for the full meeting.

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Extra info for Chemical Probes in Biology: Science at the Interface of Chemistry, Biology and Medicine

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Rapid and convergent access is provided by methods that utilize on-resin coupling of glycosylamines to aspartic acid containing peptides. As a severe side-reaction the formation of aspartimides can occur during both peptide assembly and aspartic acid activation [49]. Offer and co-workers presented a solution to this problem by using the N(4-methoxybenzyl) (Hmb) group as an amide backbone protecting group [50]. The group of Danishefsky reported a conceptually different method [51]. The glycopeptide was anchored to the solid support via the carbohydrate part rather than the peptide C-terminus.

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Chemical Probes in Biology: Science at the Interface of Chemistry, Biology and Medicine by Jason P. Eiserich (auth.), Manfred P. Schneider (eds.)


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