By Icon Health Publications
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Additional info for Cholestasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Associate Professor of Human Genetics In; Children's Hospital of Philadelphia 34Th St and Civic Ctr Blvd Philadelphia, Pa 191044399 Timing: Fiscal Year 2002 Summary: This abstract is not available. ; Professor and Chair; Cellular/Molecular Physiology; University of North Carolina Chapel Hill Aob 104 Airport Drive Cb#1350 Chapel Hill, Nc 27599 Timing: Fiscal Year 2003; Project Start 01-FEB-1992; Project End 30-JUN-2008 Summary: (provided by applicant): The long-range goal of this project is to understand the molecular basis for regulating paracellular transport of solutes across the tight junctions of epithelia in the gastrointestinal tract and liver.
The long term goals of these studies are to 1) characterize the structure, function and mechanism of action of mEH as a bile acid transporter, and 2) characterize alterations in mEH expression or structure leading to defects in transport. The specific aims of this proposal are to characterize a) the membrane architecture of mEH, b) the effects of expression levels, mediated by development, pregnancy and drugs, on the targeting and functional expression of mEH at the plasma membrane and c) mutations in the mEH gene (EPHX1) in subjects with hypercholanemia to establish the molecular basis for the observed transport defects.
We now apply for a 5-year renewal of our Program Project Grant (Years 26-30) that will allow us to further study these phenomena through an integrated and multidisciplinary approach. We propose to focus on 25 key molecules involved in three biological processes: 1) cholesterol and fatty acid metabolism (SREBP-1a, SREBP-1c, SREBP-2, SCAP, Site-1 protease, Site-2 protease, LDL receptor, HMG CoA reductase, fatty acid synthase, acetyl CoA synthase, IRS-1, IRS-2); 2) oxysterol and bile acid metabolism (cholesterol 7alpha-hydroxylase, oxysterol 7alpha-hydroxylase-1 and -2, cholesterol 24hydroxylase, cholesterol 25-hydroxylase, sterol 27-hydroxylase); and 3) caveolae membrane system and cell signaling (caveolin-1, LRP, VLDL receptor, ApoER2, Reelin, RAP, HDL receptor).
Cholestasis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications