By B. Beutler, E. M. Y. Moresco (auth.), Bruce Beutler (eds.)
This monograph bargains with the effect of classical genetics in immunology, prov- ing examples of ways huge immunological questions have been solved, and new fields opened to research throughout the research of phenotypes, both spontaneous or prompted. As huge as biology has turn into, there are those that don't totally comprehend what the genetic method is, and the way it differs essentially from lots of the equipment on hand to common scientists. they might carry the opinion that genetics has run its path for the reason that Mendel learn his paper on peas in 1865. “Why hassle with classical genetics,” they might ask. “Won’t all genes be knocked out quickly anyway?” Or they're intimidated via genetics, with its heavy reliance on version organisms that appear so alien. “What has C. elegans to do with me?” the wondering may possibly pass. “It doesn’t also have lymphocytes. ” Such skeptics can be unaware that the mouse is quick changing into as tractable a version organism because the fly, and that people is probably not too some distance at the back of. So i need to introduce the subject with a couple of phrases in regards to the energy of genetics, and why it has contributed rather a lot to immunology, and to bi- ogy often. Genetics, because the be aware is used the following, isn't only the technology of heredity, yet even more than that. it's the technological know-how of exceptions: the technology that takes notice of heritable version and seeks to provide an explanation for it on the such a lot basic level.
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Additional resources for Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
Science 249:1431–1433 Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111–115 Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S (2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420:324–329 Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S (2003a) Role of adaptor TRIF in the MyD88-independent tolllike receptor signaling pathway.
28 30 30 34 38 40 42 42 45 48 48 Abstract Susceptibility to infectious diseases has long been known to have a genetic component in human populations. This genetic effect is often complex and difficult to study as it is further modified by environmental factors including the disease-causing pathogen itself. The laboratory mouse has proved a useful alternative to implement a genetic approach to study host defenses against infections. Our laboratory has used genetic analysis and positional cloning to characterize single and multi-gene effects regulating inter-strain differences in the susceptibility of A/J and C57BL/6J mice to infection with several bacterial and parasitic pathogens.
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 30 30 34 38 40 42 42 45 48 48 Abstract Susceptibility to infectious diseases has long been known to have a genetic component in human populations. This genetic effect is often complex and difficult to study as it is further modified by environmental factors including the disease-causing pathogen itself. The laboratory mouse has proved a useful alternative to implement a genetic approach to study host defenses against infections.
Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology by B. Beutler, E. M. Y. Moresco (auth.), Bruce Beutler (eds.)