By Kumar Rinesh Sinha Basant K.
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Additional resources for Principles of Animal Cell Culture: Students Compendium
I) Passive Transport :- This includes physical mechanism in which the forces that derive the substances across the membrane are supplied from the environment of the cell. This type of the transport requires neither activity nor energy expenditure by the cell. Passively transported molecules, such as ions, some solutes and water pass through the lipid bilayer by the process of diffusion, or pores bordered by channel proteins which have central core of water molecule or binding to transport protein that carry the substance across the membrane and release on the other side.
Platelet Derived Growth Factor (PDGF):- It is the principal mitogen found in mammalian serum and is released froma-granule of platelet during blood clotting at the site of wound (Ross et al. 1986). PDGF elicits multifunctional actions with a variety of cells including mitogenesis of mesoderm derived cells, increased extracellular matrix synthesis and chemotaxis and activation of neutrophils, monocytes and fibroblasts. PDGF also acts as mitogen for dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes.
Vi) It insulates cells and tissues from one another and thus minimizes friction at joints and facilitates the movements of cells. (vii) It is responsible for the filtering properties of the kidney. C. Cell-adhesion Molecules : Cell adhesion molecule is the link between the cell-cell interaction and extracellular molecules (Wilson 1996). Signalling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune response, wound healing and malignant transformation, however, it is only recently realized that cell adhesion molecules are capable of transducing biochemical signals across the plasma membrane to regulate cellular functions.
Principles of Animal Cell Culture: Students Compendium by Kumar Rinesh Sinha Basant K.