By Feroze N. Ghadially
This ebook is a mixture of textbook and atlas overlaying the pathology of the cellphone as printed by means of electron microscopy. The publication is for all who on a regular basis research tissues and want to grasp in regards to the subcellular abnormalities linked to pathological states. the writer has aimed to catalogue, classify, describe and illustrate almost each intracellular lesion. during this re-creation the writer has revised and up to date the textual content and extra new fabric. Feroze Ghadially is the writer of ''Fine constitution of Synovial Joints'', ''Diagnostic Ultrastructural Pathology'' and ''Diagnostic Electron Microscopy of Tumours'' - second variation
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Extra info for Ultrastructural Pathology of the Cell and Matrix. A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components
4. M y e l i n o s o m e s found in a synovial intimal cell. F r o m a rabbit knee j o i n t after intra-articular injection of egg yolk. X 3 2 0 0 0 (Ghadially and Mehta, unpublished electron micrograph) 618 619 Myelinosomes in great numbers are found in certain inborn errors of metabolism or storage diseases, which are n o w also referred to as 'inborn lysosomal diseases' or 'lysosomal storage diseases'. These bodies have been given various names such as 'lipid cytosomes', ' m u l t i m e m b r a n o u s bodies', 'lamellar bodies', ' m e m b r a n o u s cytoplasmic bodies' and 'zebra bodies'.
605 I have not seen indubitable R-bodies filled with 'solid' rods and elongated vesicles in the jejunal biopsies that I have examined. However, multivesicular bodies containing rounded vesicles were encountered (Plate 258, Fig. 3) and at times, bodies containing oval and elongated vesicles (reminiscent of those seen in R-bodies) were also seen. In a jejunal biopsy from a patient with rheumatoid arthritis w h o had received chrysotherapy (Myochrysine), gold deposits of characteristic m o r p h o l o g y (like those seen in Plates 322-324) were detected in the subepithelial macrophages but not in the multivesicular bodies.
X 48 000 (From Ghadially, Meachim and Collins, 1965) Fig. 5. M a t r i x of h u m a n articular cartilage, s h o w i n g lipidic debris which presents as osmiophilic granular material. X 48 000 (From Ghadially, Meachim and Collins, 1965) 614 615 Myelinoid membranes and myelin figures are readily produced in tissues fixed in glutaraldehyde (Ericsson and Biberfeld, 1967), particularly if the fixation is prolonged for m a n y hours or days. Since lipids are not fixed by glutaraldehyde, some lipids leach out of the cytomembranes.
Ultrastructural Pathology of the Cell and Matrix. A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components by Feroze N. Ghadially